Developmental enhancers and chromosome topology
EEM Furlong, M Levine - Science, 2018 - science.org
Developmental enhancers mediate on/off patterns of gene expression in specific cell types
at particular stages during metazoan embryogenesis. They typically integrate multiple …
at particular stages during metazoan embryogenesis. They typically integrate multiple …
[HTML][HTML] Chromatin domains: the unit of chromosome organization
How eukaryotic chromosomes fold inside the nucleus is an age-old question that remains
unanswered today. Early biochemical and microscopic studies revealed the existence of …
unanswered today. Early biochemical and microscopic studies revealed the existence of …
[HTML][HTML] Targeted degradation of CTCF decouples local insulation of chromosome domains from genomic compartmentalization
The molecular mechanisms underlying folding of mammalian chromosomes remain poorly
understood. The transcription factor CTCF is a candidate regulator of chromosomal …
understood. The transcription factor CTCF is a candidate regulator of chromosomal …
[HTML][HTML] TIA1 mutations in amyotrophic lateral sclerosis and frontotemporal dementia promote phase separation and alter stress granule dynamics
IR Mackenzie, AM Nicholson, M Sarkar, J Messing… - Neuron, 2017 - cell.com
Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are age-related
neurodegenerative disorders with shared genetic etiologies and overlapping clinical and …
neurodegenerative disorders with shared genetic etiologies and overlapping clinical and …
[HTML][HTML] The 3D genome as moderator of chromosomal communication
Proper expression of genes requires communication with their regulatory elements that can
be located elsewhere along the chromosome. The physics of chromatin fibers imposes a …
be located elsewhere along the chromosome. The physics of chromatin fibers imposes a …
[HTML][HTML] Topologically associating domain boundaries that are stable across diverse cell types are evolutionarily constrained and enriched for heritability
E McArthur, JA Capra - The American Journal of Human Genetics, 2021 - cell.com
Topologically associating domains (TADs) are fundamental units of three-dimensional (3D)
nuclear organization. The regions bordering TADs—TAD boundaries—contribute to the …
nuclear organization. The regions bordering TADs—TAD boundaries—contribute to the …
[HTML][HTML] Dynamic organization of chromatin domains revealed by super-resolution live-cell imaging
T Nozaki, R Imai, M Tanbo, R Nagashima, S Tamura… - Molecular cell, 2017 - cell.com
The eukaryotic genome is organized within cells as chromatin. For proper information
output, higher-order chromatin structures can be regulated dynamically. How such structures …
output, higher-order chromatin structures can be regulated dynamically. How such structures …
[HTML][HTML] Disruption of chromatin folding domains by somatic genomic rearrangements in human cancer
Chromatin is folded into successive layers to organize linear DNA. Genes within the same
topologically associating domains (TADs) demonstrate similar expression and histone …
topologically associating domains (TADs) demonstrate similar expression and histone …
[HTML][HTML] Insulated neighborhoods: structural and functional units of mammalian gene control
Understanding how transcriptional enhancers control over 20,000 protein-coding genes to
maintain cell-type-specific gene expression programs in all human cells is a fundamental …
maintain cell-type-specific gene expression programs in all human cells is a fundamental …
Pan-cancer analysis of somatic copy-number alterations implicates IRS4 and IGF2 in enhancer hijacking
Extensive prior research focused on somatic copy-number alterations (SCNAs) affecting
cancer genes, yet the extent to which recurrent SCNAs exert their influence through …
cancer genes, yet the extent to which recurrent SCNAs exert their influence through …