Chromosome large‐scale organization is a beautiful example of the interplay between
physics and biology. DNA molecules are polymers and thus belong to the class of molecules …

Nuclear organization has emerged as a potential key regulator of genome function. During
development, the deployment of transcriptional programs must be tightly coordinated with …

Eukaryotic chromatin is a complex of nucleic acids and proteins that is central to interpreting
the information coded in the genome. Chromatin is rather irregularly folded inside the …

We use molecular dynamics simulations based on publicly available micrococcal nuclease
sequencing data for nucleosome positions to predict the 3D structure of chromatin in the …

Lineage-specific cell differentiation is a precise and coordinated biological process. To
explore the roles of long noncoding RNA (lncRNA) in this process, the expression of polyA …

Motivated by experiments connecting linker histone (LH) deficiency to lymphoma
progression and retinal disorders, we study by mesoscale chromatin modeling how LH …

Eukaryotic DNA is highly organized within nuclei and this organization is important for
genome function. Fluorescent in situ hybridization (FISH) approaches allow 3D architectures …

Chromosome is composed of many distinct chromatin domains, referred to variably as
topological domains or topologically associating domains (TADs). The domains are stable …

In mammals, genomic DNA that is roughly 2 m long is folded to fit the size of the cell nucleus
that has a diameter of about 10 μm. The folding of genomic DNA is mediated via assembly of …

Recent years have witnessed an explosion of the single‐cell biochemical toolbox including
chromosome conformation capture (3C)‐based methods that provide novel insights into …