[HTML][HTML] A comprehensive review of human trophoblast fusion models: recent developments and challenges
X Li, ZH Li, YX Wang, TH Liu - Cell Death Discovery, 2023 - nature.com
As an essential component of the maternal-fetal interface, the placental syncytiotrophoblast
layer contributes to a successful pregnancy by secreting hormones necessary for …
layer contributes to a successful pregnancy by secreting hormones necessary for …
[HTML][HTML] Revolutionizing the female reproductive system research using microfluidic chip platform
J Yan, T Wu, J Zhang, Y Gao, JM Wu… - Journal of …, 2023 - Springer
Comprehensively understanding the female reproductive system is crucial for safeguarding
fertility and preventing diseases concerning women's health. With the capacity to simulate …
fertility and preventing diseases concerning women's health. With the capacity to simulate …
[HTML][HTML] Healthy and diseased placental barrier on-a-chip models suitable for standardized studies
G Rabussier, I Bünter, J Bouwhuis, C Soragni… - Acta Biomaterialia, 2023 - Elsevier
Pathologies associated with uteroplacental hypoxia, such as preeclampsia are among the
leading causes of maternal and perinatal morbidity in the world. Its fundamental …
leading causes of maternal and perinatal morbidity in the world. Its fundamental …
Flow in fetoplacental-like microvessels in vitro enhances perfusion, barrier function, and matrix stability
M Cherubini, S Erickson, P Padmanaban… - Science …, 2023 - science.org
Proper placental vascularization is vital for pregnancy outcomes, but assessing it with
animal models and human explants has limitations. We introduce a 3D in vitro model of …
animal models and human explants has limitations. We introduce a 3D in vitro model of …
[HTML][HTML] Are the Organoid Models an Invaluable Contribution to ZIKA Virus Research?
P Marrazzo, M Cricca, C Nastasi - Pathogens, 2021 - mdpi.com
In order to prevent new pathogen outbreaks and avoid possible new global health threats, it
is important to study the mechanisms of microbial pathogenesis, screen new antiviral agents …
is important to study the mechanisms of microbial pathogenesis, screen new antiviral agents …
Endocrine-disrupting compounds and their impact on human placental function: evidence from placenta organ-on-chip studies
The effects of endocrine-disrupting compounds (EDCs) on the placenta, a critical gestational
organ for xenobiotic protection, are well reported; however, models to determine the role of …
organ for xenobiotic protection, are well reported; however, models to determine the role of …
First‐trimester plasma extracellular heat shock proteins levels and risk of preeclampsia
CM Robellada‐Zárate… - Journal of Cellular …, 2023 - Wiley Online Library
Preeclampsia (PE) occurs annually in 8% of pregnancies. Patients without risk factors
represent 10% of these. There are currently no first‐trimester biochemical markers that …
represent 10% of these. There are currently no first‐trimester biochemical markers that …
[HTML][HTML] 3D microfluidics-assisted modeling of glucose transport in placental malaria
B Mosavati, A Oleinikov, E Du - Scientific Reports, 2022 - nature.com
The human placenta is a critical organ, mediating the exchange of nutrients, oxygen, and
waste products between fetus and mother. Placental malaria (PM) resulted from …
waste products between fetus and mother. Placental malaria (PM) resulted from …
Beyond 2D: Novel biomaterial approaches for modeling the placenta
This review considers fully three-dimensional biomaterial environments of varying
complexity as these pertain to research on the placenta. The developments in placental cell …
complexity as these pertain to research on the placenta. The developments in placental cell …
In vitro toxicology: Next generation models and methods to improve safety evaluation
MC Fortin, J Szilagyi - Drug Discovery and Evaluation: Safety and …, 2023 - Springer
With the advent of molecular and cellular toxicology, the field of drug safety evaluation has
been undergoing an important paradigm shift, which has recently been further incentivized …
been undergoing an important paradigm shift, which has recently been further incentivized …