Immunocompromised individuals are at high risk of developing severe fungal infections with
high mortality rates, while fungal pathogens pose little risk to most healthy people. Poor …

The sheet‐like lipid bilayer is the fundamental structural component of all cell membranes.
Its building blocks are phospholipids and cholesterol. Their amphiphilic structure …

We previously reported that administration of Cryptococcus neoformans Δsgl1 mutant
vaccine, accumulating sterylglucosides (SGs) and having normal capsule (GXM), protects …

Sphingolipids are a structurally diverse class of lipids predominantly found in the plasma
membrane of eukaryotic cells. These lipids can laterally segregate with other rigid lipids and …

Sphingolipids (SLs) are essential to fungal survival and represent a major class of structural
and signaling lipids. Unique SL structures and their biosynthetic enzymes in filamentous …

Besides participating in diverse pathological and physiological processes, extracellular
vesicles (EVs) are also excellent drug‐delivery vehicles. However, clinical drugs modulating …

Interleaflet coupling—the influence of one leaflet on the properties of the opposing leaflet—
is a fundamental plasma membrane organizational principle. This coupling is proposed to …

Sphingolipids are critically significant in a range of biological processes in animals, plants,
and fungi. In mammalian cells, they serve as vital components of the plasma membrane …

Inhibitory natural killer (NK) cell receptors recognize MHC class I (MHC-I) in trans on target
cells and suppress cytotoxicity. Some NK cell receptors recognize MHC-I in cis, but the role …

Fungal infections present a significant global public health concern, impacting over 1 billion
individuals worldwide and resulting in more than 3 million deaths annually. Despite …