Inflammasomes are critical sentinels of the innate immune system that respond to threats to
the host through recognition of distinct molecules, known as pathogen-or damage …

Inflammasomes are large cytosolic multiprotein complexes assembled in response to
infection and cellular stress, and are crucial for the activation of inflammatory caspases and …

Organelles are critical structures in mediating the assembly and activation of
inflammasomes in mammalian cells, resulting in inflammation and cell death. Assembly of …

Monitoring of the cytosolic compartment by the innate immune system for pathogen-encoded
products or pathogen activities often enables the activation of a subset of caspases. In most …

Summary Caspase-11, a cytosolic endotoxin (lipopolysaccharide: LPS) receptor, mediates
pyroptosis, a lytic form of cell death. Caspase-11-dependent pyroptosis mediates lethality in …

Endothelium (EC) is a key component of blood–brain barrier (BBB), and has an important
position in the neurovascular unit. Its dysfunction and death after cerebral …

Sepsis has been identified by the World Health Organization (WHO) as a global health
priority. There has been a tremendous effort to decipher underlying mechanisms …

Sepsis is defined as life-threatening organ dysfunction caused by a dysregulated host
response to infection. Recently was been found that pyroptosis is a unique form of …

Necroptosis is a genetically regulated form of necrotic cell death that has emerged as an
important pathway in human disease. The necroptosis pathway is induced by a variety of …

Sepsis is a life-threatening condition caused by pathogen infection and associated with
pyroptosis. Pyroptosis occurs upon activation of proinflammatory caspases and their …