Intracellular surveillance for systemic microbial components during homeostasis and
infections governs host physiology and immunity. However, a long-standing question is how …

Unchecked inflammation is a hallmark of inflammatory tissue injury in diseases such as
acute respiratory distress syndrome (ARDS). Yet the mechanisms of inflammatory lung injury …

Inflammation and tubular cell death are the hallmarks of acute kidney injury. However, the
precise mechanism underlying these effects has not been fully elucidated. Here we tested …

Inflammatory caspase sensing of cytosolic lipopolysaccharide (LPS) triggers pyroptosis and
the concurrent release of damage-associated molecular patterns (DAMPs). Collectively …

The inflammasome is a three-component (sensor, adaptor, and effector) filamentous
signaling platform that shields from multiple pathogenic infections by stimulating the …

Pyroptosis is a programmed necrotic cell death executed by gasdermins, a family of pore-
forming proteins. The cleavage of gasdermins by specific proteases enables their pore …

Pyroptosis, a newly discovered form of programmed cell death, is characterized by cell
swelling, the protrusion of large bubbles from the plasma membrane and cell lysis. This …

Sepsis is defined as organ dysfunction due to a dysregulated systemic host response to
infection. During gram-negative bacterial infection and other acute illness such as …

Pyroptosis is a novel inflammatory form of regulated cell death (RCD), characterized by cell
swelling, membrane rupture, and pro-inflammatory effects. It is recognized as a potent …

Background Emodin has recently been reported to have a powerful antiinflammatory effect,
protecting the myocardium against ischemia/reperfusion (I/R) injury. Pyroptosis is a …