AI in drug discovery and its clinical relevance
The COVID-19 pandemic has emphasized the need for novel drug discovery process.
However, the journey from conceptualizing a drug to its eventual implementation in clinical …
However, the journey from conceptualizing a drug to its eventual implementation in clinical …
Toxicity testing in the 21st century: progress in the past decade and future perspectives
D Krewski, ME Andersen, MG Tyshenko… - Archives of …, 2020 - Springer
Advances in the biological sciences have led to an ongoing paradigm shift in toxicity testing
based on expanded application of high-throughput in vitro screening and in silico methods …
based on expanded application of high-throughput in vitro screening and in silico methods …
[HTML][HTML] Artificial intelligence in drug discovery: what is realistic, what are illusions? Part 2: a discussion of chemical and biological data
A Bender, I Cortes-Ciriano - Drug Discovery Today, 2021 - Elsevier
Highlights•Drug discovery data and data from other sources are different in quantity and
characteristics.•This article underlines the difference of data from different domains.•In order …
characteristics.•This article underlines the difference of data from different domains.•In order …
Utility of In Vitro Bioactivity as a Lower Bound Estimate of In Vivo Adverse Effect Levels and in Risk-Based Prioritization
K Paul Friedman, M Gagne, LH Loo… - Toxicological …, 2020 - academic.oup.com
Use of high-throughput, in vitro bioactivity data in setting a point-of-departure (POD) has the
potential to accelerate the pace of human health safety evaluation by informing screening …
potential to accelerate the pace of human health safety evaluation by informing screening …
Docking techniques in pharmacology: How much promising?
Docking techniques in pharmacology: How much promising? - ScienceDirect Skip to main
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IVIVE: Facilitating the Use of In Vitro Toxicity Data in Risk Assessment and Decision Making
X Chang, YM Tan, DG Allen, S Bell, PC Brown… - Toxics, 2022 - mdpi.com
During the past few decades, the science of toxicology has been undergoing a
transformation from observational to predictive science. New approach methodologies …
transformation from observational to predictive science. New approach methodologies …
[HTML][HTML] Occurrence, hazard, and risk of psychopharmaceuticals and illicit drugs in European surface waters
CJE Davey, MHS Kraak, A Praetorius, TL Ter Laak… - Water Research, 2022 - Elsevier
This study aimed to provide insights into the risk posed by psychopharmaceuticals and illicit
drugs in European surface waters, and to identify current knowledge gaps hampering this …
drugs in European surface waters, and to identify current knowledge gaps hampering this …
TOXRIC: a comprehensive database of toxicological data and benchmarks
L Wu, B Yan, J Han, R Li, J Xiao, S He… - Nucleic Acids …, 2023 - academic.oup.com
The toxic effects of compounds on environment, humans, and other organisms have been a
major focus of many research areas, including drug discovery and ecological research …
major focus of many research areas, including drug discovery and ecological research …
[图书][B] Bioanalytical tools in water quality assessment
The first edition of Bioanalytical Tools in Water Quality Assessment was released in 2012.
The field has exploded since and the second edition updates and reviews the application of …
The field has exploded since and the second edition updates and reviews the application of …
Development of a roadmap for action on new approach methodologies in risk assessment
SE Escher, F Partosch, S Konzok… - EFSA Supporting …, 2022 - Wiley Online Library
While whole animal studies have their place in risk assessment of food and feed
components, it is thought that more modern approaches such as human focused new …
components, it is thought that more modern approaches such as human focused new …