Phosphodiesterases (PDEs), enzymes that degrade 3′, 5′-cyclic nucleotides, are being
pursued as therapeutic targets for several diseases, including those affecting the nervous …

Cancer immunotherapy has witnessed significant advances in the past decade, however
challenges associated with immune‐related adverse effects and immunosuppressive tumor …

Cancer stem-like cells (CSCs) contribute to cancer metastasis, drug resistance and tumor
relapse, yet how amino acid metabolism promotes CSC maintenance remains exclusive …

Introduction Colorectal cancer (CRC) is a devastating disease that affects millions of people
worldwide. Recent research has highlighted the crucial role of the guanylate cyclase-C (GC …

Colorectal cancer (CRC) is the third most common cancer, with a high mortality rate and a
serious impact on people's life and health. In recent years, adoptive chimeric antigen …

Receptor Guanylyl Cyclase C (GC-C) was initially characterized as an important regulator of
intestinal fluid and ion homeostasis. Recent findings demonstrate that GC-C is also causally …

Colorectal cancer is the third most frequently diagnosed cancer malignancy and the second
leading cause of cancer-related deaths worldwide. Therefore, it is of utmost importance to …

Background & Aims Phosphodiesterase 5 (PDE5) inhibitors have been proposed to have
chemopreventative effects on colorectal cancer (CRC), although data are needed from …

Abstract Background N6-methyladenosine (m6A) modification and long non-coding RNAs
(lncRNAs) play pivotal roles in gastric cancer (GC) progression. The emergence of …

Nitric oxide (NO)/cyclic guanosine 3′, 5′-monophosphate (cGMP) signaling has been
shown to act as a mediator involved in pain transmission and processing. In this review, we …