Transitions between epithelial and mesenchymal phenotypes–the epithelial to
mesenchymal transition (EMT) and its reverse the mesenchymal to epithelial transition …

Multistability or coexistence of different attractors for a given set of parameters is one of the
most exciting phenomena in dynamical systems. It can be found in different areas of science …

In order to understand the functioning of organisms on the molecular level, we need to know
which genes are expressed, when and where in the organism, and to which extent. The …

Physical Biology of the Cell is a textbook for a first course in physical biology or biophysics
for undergraduate or graduate students. It maps the huge and complex landscape of cell …

Waddington's epigenetic landscape is probably the most famous and most powerful
metaphor in developmental biology. Cells, represented by balls, roll downhill through a …

Secreted signals, known as morphogens, provide the positional information that organizes
gene expression and cellular differentiation in many developing tissues. In the vertebrate …

Transcriptional regulation is an inherently noisy process. The origins of this stochastic
behavior can be traced to the random transitions among the discrete chemical states of …

Gene expression control based on CRISPRi (clustered regularly interspaced short
palindromic repeats interference) has emerged as a powerful tool for creating synthetic gene …

Bistable biochemical switches are widely found in gene regulatory networks and signal
transduction pathways. Their switching dynamics are difficult to study, however, because …

The generation of cellular diversity during development involves differentiating cells
transitioning between discrete cell states. In the 1940s, the developmental biologist Conrad …