There is a widespread presence of both adenosine (P1) and P2 nucleotide receptors in the
brain on both neurones and glial cells. Adenosine receptors play a major role in presynaptic …

In the pursuit of improved treatments for Parkinson's disease (PD), the adenosine A2A
receptor has emerged as an attractive nondopaminergic target. Based on the compelling …

In addition to its direct pre-and postsynaptic actions on neurones, adenosine is rich in
nuances of priming, triggering and inhibiting the action of several neurotransmitters and …

Activation of adenosine A2A receptors (A2AR) has been shown to antagonize the function of
D2 dopaminergic regulation of striatal γ‐aminobutyric acid (GABA)‐ergic output and, thus …

Parkinson's disease (PD) is characterized by a progressive loss of nigrostriatal
dopaminergic neurons associated with intracellular Lewy inclusion bodies. The result is …

The remarkable prevalence of pyrazole scaffolds in a versatile array of bioactive molecules
ranging from apixaban, an anticoagulant used to treat and prevent blood clots and stroke, to …

Human and animal studies have converged to suggest that caffeine consumption prevents
memory deficits in aging and Alzheimer's disease through the antagonism of adenosine A …

Adenosine is an important mediator of ethanol intoxication. In vitro, ethanol stimulates
adenosine signaling by inhibiting the type 1 equilibrative nucleoside transporter (ENT1) …

Adenosine A2A receptors are most abundant in the striatum where they control the
striatopallidal pathway thus controlling locomotion. Extra-striatal A2A receptors are …

Brain adenosine A2A receptors have recently attracted considerable attention because of
their interaction with the dopaminergic system and as potential targets for Parkinson's …