Prenatal detection of chromosome abnormalities has been offered for more than 40 years,
first by amniocentesis in the early 1970s and additionally by chorionic villus sampling (CVS) …

Abstract Objective To develop a Canadian consensus document on maternal screening for
fetal aneuploidy (eg, Down syndrome and trisomy 18) in singleton pregnancies. Options …

Objective This study aims to develop a noninvasive prenatal test on the basis of the analysis
of cell‐free DNA in maternal blood to detect fetal aneuploidy at chromosomes 13, 18, 21, X …

Background It is uncertain how best to screen pregnant women for the presence of fetal
Down's syndrome: to perform first-trimester screening, to perform second-trimester …

Objective To 'map'the current (2004) state of prenatal screening in Europe. Design (i) Survey
of country policies and (ii) analysis of data from EUROCAT (European Surveillance of …

Background Both first-trimester screening and second-trimester screening for Down's
syndrome are effective means of selecting women for chorionic-villus sampling or …

ContextSecond-trimester prenatal ultrasound is widely used in an attempt to detect Down
syndrome in fetuses, but the accuracy of this method is unknown. ObjectiveTo determine the …

Objective. Since 1964, researchers have been examining the ways in which physicians
deliver a postnatal diagnosis of Down syndrome (DS). Almost all of the studies, however …

Objective To evaluate the introduction of a one stop multidisciplinary clinic for screening for
fetal chromosomal abnormalities in the first trimester by a combination of maternal serum …

Pregnancy and childbirth typically are associated with positive emotions and with
motherhood, but the reality is that this is not the case for all women or for all pregnancies …