Fatty acid metabolism is known to support tumorigenesis and disease progression as well
as treatment resistance through enhanced lipid synthesis, storage and catabolism. More …

Brown adipose tissue (BAT) displays the unique capacity to generate heat through
uncoupled oxidative phosphorylation that makes it a very attractive therapeutic target for …

Obesity is increasingly prevalent and is associated with substantial cardiovascular risk.
Adipose tissue distribution and morphology play a key role in determining the degree of …

In adipocytes the hydrolysis of TAG to produce fatty acids and glycerol under fasting
conditions or times of elevated energy demands is tightly regulated by neuroendocrine …

Triacylglycerol (TAG) stored in adipose tissue (AT) can be rapidly mobilized by the hydrolytic
action of the three main lipases of the adipocyte. The non-esterified fatty acids (NEFA) …

Physical activity and exercise are key components of energy expenditure and therefore of
energy balance. Changes in energy balance alter fat mass. It is therefore reasonable to ask …

Indirect evidence from human studies suggests that brown adipose tissue (BAT)
thermogenesis is fueled predominantly by fatty acids hydrolyzed from intracellular …

Key points Both brown adipose tissue (BAT) and skeletal muscle activation contribute to the
metabolic response of acute cold exposure in healthy men even under minimal shivering …

Increases in adipocyte volume and tissue mass due to obesity can result in inflammation,
further dysregulation in adipose tissue function, and eventually adipose tissue fibrosis. Like …

Disturbances in fatty acid metabolism in adipose tissue, liver, skeletal muscle, gut and
pancreas play an important role in the development of insulin resistance, impaired glucose …