The second most common age-related neurodegenerative illness is Parkinson's disease
(PD). The animal model of Parkinson's disease known as the rotenone rat model is well …

Background: Exercise and Curcumin have positive effects on spatial memory and cognition
independently. The present study aims to investigate whether the combination of ineffectual …

The broad variety of substances that inhibit the action of the ubiquitin-proteasome system
(UPS)—known as proteasome inhibitors—have been used extensively in previous studies …

This study investigated the potential adverse effects of dimethyl sulfoxide (DMSO), focusing
on the development of hydrocephalus. DMSO is a commonly used solvent in the medical …

Dimethyl sulfoxide (DMSO) is commonly used as control or vehicle solvent in preclinical
research of neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS) due to …

Background Acute ischemia and reperfusion in extremities ignite a complicated
inflammatory cycle and lead to damage in the extremities and target tissues. Methods Rats …

Adult neurogenesis occurs in the hippocampal dentate gyrus (DG) and lateral ventricles,
and includes cell proliferation and neuronal differentiation, maturation and survival. In vitro …

Oxidative stress has been implicated as a central pathogenic mechanism in traumatic brain
injury (TBI) because the brain is especially vulnerable to such stress, compared to other …

Abstract The journal Restorative Neurology and Neuroscience (RNN) now celebrates its
20th anniversary. Since 1989 RNN has published scientific findings in the emerging fields of …

As the underlying pathophysiology of progressive forms of multiple sclerosis (MS) are
unclear, current treatment strategies remain inadequate. Progressive MS is associated with …