Flipping the metabolic switch: understanding and applying the health benefits of fasting

SD Anton, K Moehl, WT Donahoo, K Marosi, SA Lee… - …, 2018 - Wiley Online Library
Objective Intermittent fasting (IF) is a term used to describe a variety of eating patterns in
which no or few calories are consumed for time periods that can range from 12 hours to …

The effects of aging in the hippocampus and cognitive decline

LEB Bettio, L Rajendran, J Gil-Mohapel - Neuroscience & Biobehavioral …, 2017 - Elsevier
Aging is a natural process that is associated with cognitive decline as well as functional and
social impairments. One structure of particular interest when considering aging and …

[HTML][HTML] The effects of time restricted feeding on overweight, older adults: a pilot study

SD Anton, SA Lee, WT Donahoo, C McLaren, T Manini… - Nutrients, 2019 - mdpi.com
A growing body of evidence indicates that time restricted feeding (TRF), a popular form of
intermittent fasting, can activate similar biological pathways as caloric restriction, the only …

[HTML][HTML] The biology of aging and cancer: a brief overview of shared and divergent molecular hallmarks

JR Aunan, WC Cho, K Søreide - Aging and disease, 2017 - ncbi.nlm.nih.gov
Aging is the inevitable time-dependent decline in physiological organ function and is a
major risk factor for cancer development. Due to advances in health care, hygiene control …

Interventions to slow aging in humans: are we ready?

VD Longo, A Antebi, A Bartke, N Barzilai… - Aging cell, 2015 - Wiley Online Library
The workshop entitled 'Interventions to Slow Aging in Humans: Are We Ready?'was held in
Erice, Italy, on October 8–13, 2013, to bring together leading experts in the biology and …

Molecular and biological hallmarks of ageing

JR Aunan, MM Watson, HR Hagland… - Journal of British …, 2016 - academic.oup.com
Background Ageing is the inevitable time-dependent decline in physiological organ function
that eventually leads to death. Age is a major risk factor for many of the most common …

Calorie restriction and aging in humans

EW Flanagan, J Most, JT Mey… - Annual review of …, 2020 - annualreviews.org
Calorie restriction (CR), the reduction of dietary intake below energy requirements while
maintaining optimal nutrition, is the only known nutritional intervention with the potential to …

[HTML][HTML] Alternate day fasting improves physiological and molecular markers of aging in healthy, non-obese humans

S Stekovic, SJ Hofer, N Tripolt, MA Aon, P Royer… - Cell metabolism, 2019 - cell.com
Caloric restriction and intermittent fasting are known to prolong life-and healthspan in model
organisms, while their effects on humans are less well studied. In a randomized controlled …

[HTML][HTML] Intermittent fasting enhanced the cognitive function in older adults with mild cognitive impairment by inducing biochemical and metabolic changes: a 3-year …

TC Ooi, A Meramat, NF Rajab, S Shahar, IS Ismail… - Nutrients, 2020 - mdpi.com
Intermittent fasting (IF) refers to various dietary regimens that cycle between a period of non-
fasting and a period of total fasting. This study aimed to determine the effects of IF on …

Aged hematopoietic stem cells are refractory to bloodborne systemic rejuvenation interventions

TT Ho, PV Dellorusso, EV Verovskaya… - Journal of Experimental …, 2021 - rupress.org
While young blood can restore many aged tissues, its effects on the aged blood system itself
and old hematopoietic stem cells (HSCs) have not been determined. Here, we used …