The T lymphocyte, especially its capacity for antigen-directed cytotoxicity, has become a
central focus for engaging the immune system in the fight against cancer. Basic science …

While inbred mice have informed most of what we know about the immune system in the
modern era, they have clear limitations with respect to their ability to be informative …

Abstract PD-1, a 55 kDa transmembrane protein containing an immunoreceptor tyrosine-
based inhibitory motif, is induced in lymphocytes and monocytic cells following activation …

The immune system is an organization of cells and molecules with specialized roles in
defending against infection. There are two fundamentally different types of responses to …

Since the early 20th century, immunologists have investigated mechanisms that protect
vertebrates from damaging immune responses against self-antigens by mature lymphocytes …

Rheumatoid arthritis (RA) is a chronic joint disease characterized by leukocyte invasion and
synoviocyte activation followed by cartilage and bone destruction. Its etiology and …

One of the most fundamental problems in immunology is the seemingly schizophrenic ability
of the immune system to launch robust immunity against pathogens, while acquiring and …

This article discusses how recent data have altered the way we understand how dying
tumour cells, particularly those killed by chemotherapy, engage with antitumour immune …

DEVELOPMENTS in thyroid autoimmunity have been reviewed in this journal previously (1,
2), but since then there have been major advances in our understanding of the mechanisms …

Nonobese diabetic (NOD) mice spontaneously develop a disease very similar to type 1
diabetes in humans. We have generated a transgenic mouse strain carrying the rearranged …