BACKGROUND There is a great inter-individual variability of ovarian ageing, and almost
20% of patients consulting for infertility show signs of premature ovarian ageing. This …

BACKGROUND Extracellular vesicles (EVs) are membrane-bound vesicles, found in
biofluids, that carry and transfer regulatory molecules, such as microRNAs (miRNAs) and …

Primary ovarian insufficiency is a subclass of ovarian dysfunction in which the cause is
within the ovary. In most cases, an unknown mechanism leads to premature exhaustion of …

Two major functions of the mammalian ovary are the production of germ cells (oocytes),
which allow continuation of the species, and the generation of bioactive molecules, primarily …

BACKGROUND Chemotherapy treatment in premenopausal women is associated with an
increased risk of premature ovarian failure (POF) but the exact mechanism through which …

Oocyte quality is a key limiting factor in female fertility, yet we have a poor understanding of
what constitutes oocyte quality or the mechanisms governing it. The ovarian follicular …

The ovary, the female gonad, serves as the source for the germ cells as well as the major
supplier of steroid sex hormones. During embryonic development, the primordial germ cells …

The production of functional female gametes is essential for the propagation of all vertebrate
species. The growth of oocytes within ovarian follicles and their development to mature eggs …

Meiotic progression in mammalian preovulatory follicles is controlled by the granulosa cells
around the oocyte. Cyclic GMP (cGMP) generated in the granulosa cells diffuses through …

Human Blepharophimosis/ptosis/epicanthus inversus syndrome (BPES) type I is an
autosomal dominant disorder associated with premature ovarian failure (POF) caused by …