The broad interdisciplinary nature of biocatalysis fosters innovation, as different technical
fields are interconnected and synergized. A way to depict that innovation is by conducting a …

Coronary artery disease remains the major cause of mortality worldwide. Antiplatelet drugs
such as acetylsalicylic acid and P2Y12 receptor antagonists are cornerstone treatments for …

We conducted a comprehensive in vivo study evaluating the influence of type 2 diabetes
(T2D) on major cytochrome P450 (CYP 450) activities. These activities were assessed in 38 …

Antiplatelet therapy is used in the treatment of patients with acute coronary syndromes,
stroke, and those undergoing percutaneous coronary intervention. Clopidogrel is the most …

Highlights•Antiplatelet agents play a key role in the therapy of acute coronary syndromes
(ACS).•P2Y 12 antagonists inhibit processes important for both thrombosis and …

Therapeutic peptides are oligomers or short polymers of amino acids used for various
medical purposes. Peptide-based treatments have evolved considerably due to new …

The introduction of ticagrelor, one of the first directly-acting oral antiplatelet drugs, provided
new possibilities in the prevention of thrombotic events in patients with acute coronary …

Antiplatelet drugs serve as a first-line antithrombotic therapy for the management of acute
ischemic events and the prevention of secondary complications in vascular diseases …

Aims Dyspnoea often occurs in patients with acute coronary syndrome (ACS) treated with
ticagrelor compared with other anti-platelet agents and is a cause of drug discontinuation …

Ever since evidence about the increased risk of stent thrombosis with drug eluting stents
(DES) surfaced in 2005, the Food and Drug Administration (FDA) has recommended the use …