In spite of the considerable achievements in the field of regenerative medicine in the past
several decades, osteochondral defect regeneration remains a challenging issue among …

Metabolism is important for cartilage and synovial joint function. Under adverse
microenvironmental conditions, mammalian cells undergo a switch in cell metabolism from a …

Osteoarthritis is the most common joint disorder with increasing prevalence due to aging of
the population. Its multi-factorial etiology includes oxidative stress and the overproduction of …

Osteoarthritis (OA) is a progressive joint disorder that is primarily characterized by the
degeneration and destruction of the articular cartilage. Cartilage matrix degradation …

Background Rheumatoid arthritis (RA) is an autoimmune inflammatory disorder. Highly
reactive oxygen free radicals are believed to be involved in the pathogenesis of the disease …

As an essential nutrient and trace element, selenium is required for living organisms and its
beneficial roles in human health have been well recognized. The role of selenium is mainly …

Degradation of extracellular matrix (ECM) underlies loss of cartilage tissue in osteoarthritis,
a common disease for which no effective disease-modifying therapy currently exists. Here …

Purpose of Review Mitochondria are recognized to be one of the most important organelles
in chondrocytes for their role in triphosphate (ATP) generation through aerobic …

Inflammation has been linked to multiple degenerative and acute diseases as well as the
aging process. Moreover, mitochondrial alterations play a central role in these processes …

Oxidative stress has been implicated in the pathogenesis of osteoarthritis and has become
an important therapeutic target. Investigations of various antioxidant supplements, reactive …