The interaction of cells within their microenvironmental niche is fundamental to cell
migration, positioning, growth and differentiation in order to form and maintain complex …

There is a need for technologies to predict the efficacy of cancer treatment in individual
patients. Here, we show that optical metabolic imaging of organoids derived from primary …

Mitochondria play a pivotal role in energy metabolism, programmed cell death and oxidative
stress. Mutated mitochondrial DNA in diseased cells compromises the structure of key …

DNA damage signaling is critical for the maintenance of genome integrity and cell fate
decision. Poly (ADP-ribose) polymerase 1 (PARP1) is a DNA damage sensor rapidly …

Reduced nicotinamide adenine dinucleotide, NADH, is a major electron donor in the
oxidative phosphorylation and glycolytic pathways in cells. As a result, there has been …

To comprehend the complexity of cancer, the biological characteristics acquired during the
initiation and progression of tumours were classified as the'hallmarks of cancer'. Intravital …

Abstract While NAD (P) H fluorescence lifetime imaging (FLIM) can detect changes in flux
through the TCA cycle and electron transport chain (ETC), it remains unclear whether NAD …

Cancer metastasis involves complex cell behavior and interaction with the extracellular
matrix by metabolically active cells. To observe invasion and metastasis with sub-cellular …

Objectives Three-dimensional organoids derived from primary pancreatic ductal
adenocarcinomas are an attractive platform for testing potential anticancer drugs on patient …

The study of biological systems in their real environmental conditions is crucial to decipher
the true image of structures and processes underlying their functionality. In this regard …