Primary tumor organoids grown in three-dimensional culture provide an excellent platform
for studying tumor progression, invasion and drug response. However, organoid generation …

Simple Summary Complete resection of dysplastic and malignant tissue improves overall
survival and delays cancer recurrence in oral cancer patients; however, intraoperative …

The classical examination of histology slides from a mouse model of breast cancer has been
extended in this study to incorporate modern multiphoton excitation and photon-counting …

A major challenge in ART is to select high-quality oocytes and embryos. The metabolism of
oocytes and embryos has long been linked to their viability, suggesting the potential utility of …

Biophotonics is a convergent field which integrates biological physics, neurosciences,
optical physics, and nanoscience for optical diagnostics, bioimaging and light activated …

The spatiotemporal blood vessel formation and specification at the osteogenic and
angiogenic interface of murine cranial bone defect repair were examined utilizing a high …

Chronic wounds are difficult to diagnose and characterize due to a lack of quantitative
biomarkers. Label-free multiphoton microscopy has emerged as a useful imaging modality …

Type 2 diabetes is characterized by β and α cell dysfunction. We used phasor-FLIM
(Fluorescence Lifetime Imaging Microscopy) to monitor oxidative phosphorylation and …

A compact clinically compatible fluorescence lifetime imaging microscopy (FLIM) system
was designed and built for intraoperative disease diagnosis and validated in vivo in a …

The ability of stem cells to differentiate into specialized cell types presents a number of
opportunities for regenerative medicine, stem cell therapy and developmental biology …