The proliferative and functional heterogeneity among seemingly uniform cells is a universal
phenomenon. Identifying the underlying factors requires single-cell analysis of function and …

The insensitivity of multiphoton microscopy to optical scattering enables high-resolution,
high-contrast imaging deep into tissue, including in live animals. Scattering does, however …

In the mammalian brain, astrocytes form a heterogeneous population at the morphological,
molecular, functional, intra-, and inter-region levels. In the past, a few types of astrocytes …

During vertebrate development, the central (CNS) and peripheral nervous systems (PNS)
arise from the neural plate. Cells at the margin of the neural plate give rise to neural crest …

The potency of post-embryonic stem cells can only be addressed in the living organism, by
labeling single cells after embryonic development and following their descendants …

Unequal centrosome maturation correlates with asymmetric division in multiple cell types.
Nevertheless, centrosomal fate determinants have yet to be identified. Here, we show that …

Understanding the generation of complexity in living organisms requires the use of lineage
tracing tools at a multicellular scale. In this review, we describe the different multicolor …

Clonal cell analysis defines the potential of single cells and the diversity they can produce.
To achieve this, we have developed a novel adaptation of the genetic tracing strategy, UbC …

Highlights•Tissue clearing and viral vectors for resolved 3D imaging of unsevered
circuits.•Size-adjustable tissue-hydrogels for sample stabilization and selective …

Highlights•Cell lineage underlies the developmental steps taken to acquire cell
identity.•Genetic labeling allows lineage tracing with cell type and temporal …