The aim of connectomics analysis is to understand whole-brain neural connections. This is
accomplished using new biotechnologies. Here, we provide an overview of the recent …

Oriented cell divisions are controlled by a conserved molecular cascade involving Gαi, LGN,
and NuMA. We developed a new cellular model of oriented cell divisions combining …

The global mechanisms that regulate and potentially coordinate cell proliferation & death in
developing neural regions are not well understood. In particular, it is not clear how or …

The evolution of unique organ structures is associated with changes in conserved
developmental programs. However, characterizing the functional conservation and variation …

Lineage tracing is an essential tool to study stem cell fate. Although traditional lineage
tracing techniques have considerably advanced our understanding of stem cell behavior …

In various biological contexts, cells receive signals and stimuli that prompt them to change
their current state, leading to transitions into a future state. This change underlies the …

Background Marker detection is an important task in complex disease studies. Here we
provide an association rule mining (ARM) based approach for identifying integrated markers …

A fundamental issue in developmental biology and in organ homeostasis is understanding
the molecular mechanisms governing the balance between stem cell maintenance and …

Genetic lineage tracing with electroporation is one of the most powerful techniques to target
neural progenitor cells and their progeny. However, the spatiotemporal relationship between …

The mammalian cerebral cortex undergoes a strictly regulated developmental process.
Detailed in situ visualizations, imaging of these dynamic processes, and in vivo functional …