Executive summary The Sustainable Development Goals (SDGs) represent an exponential
advance from the Millennium Development Goals, with a substantially broader agenda …

Colorectal cancer is a leading cause of cancer related deaths worldwide. One of the
hallmarks of cancer and a fundamental trait of virtually all gastrointestinal cancers is …

Background Dietary restriction (DR), a reduction in food intake without malnutrition,
increases most aspects of health during aging and extends lifespan in diverse species …

Mitochondria are controlled by the coordination of two genomes: the mitochondrial and the
nuclear DNA. As such, variations in nuclear gene expression as a consequence of …

DNA methylation is one of the main epigenetic phenomena affecting gene expression. It is
an important mechanism for the development of embryo, growth and health of animals. As a …

DNA methylation is a vital modification process in the control of genetic information, which
contributes to the epigenetics by regulating gene expression without changing the DNA …

Nonalcoholic fatty liver disease (NAFLD) is a chronic, frequently progressive condition that
develops in response to excessive hepatocyte fat accumulation (ie, steatosis) in the absence …

People differ in their requirements for and responses to nutrients and bioactive molecules in
the diet. Many inputs contribute to metabolic heterogeneity (including variations in genetics …

Diet bioactive components, in the concept of nutrigenetics and nutrigenomics, consist of food
constituents, which can transfer information from the external environment and influence …

Understanding the relationship between genotype and phenotype is a central goal not just
for genetics but also for medicine and biological sciences. Despite outstanding …