Since their invention in the early 2000s, tyrosine kinase inhibitors (TKIs) have gained
prominence as the most effective pathway-directed anti-cancer agents. TKIs have shown …

Tyrosine kinase inhibitors (TKIs) have improved outcome for many tumors. Although better
tolerated than cytotoxic chemotherapy, they may cause several adverse events (AEs) and …

Background: Over the past decades, advancements in oncological treatments have led to
major improvements in survival. Particularly for adolescents and young adults (AYAs) …

PURPOSE To review the complex concerns of oncofertility created through increased
cancer survivorship and the long-term effects of cancer treatment in young adults. DESIGN …

Abstract Purpose of Review Although fertility preservation is not yet fully integrated into the
comprehensive cancer care of pediatric and adolescent patients, advances continue to take …

Background Chemotherapy is one of the causes of ovarian injury and infertility. Although
assisted reproductive technology helps young female patients with cancer become …

The management of potentially life-threatening malignancies in pregnancy is complicated by
a lack of robust safety and efficacy evidence. This data shortage stems from a historical …

Background Given the increasing number and survival rates of reproductive-age patients
with chronic myeloid leukemia (CML), several studies aimed to elucidate optimum disease …

Targeted cancer therapy is rapidly evolving the landscape of personalized health care.
Novel approaches to selectively impeding tumour growth carry significant potential to …

Human prepubertal testicular tissues are rare, but organ culture conditions to develop a
system for human in vitro-spermatogenesis are an essential option for fertility preservation in …