Uterine bleeding: how understanding endometrial physiology underpins menstrual health

V Jain, RR Chodankar, JA Maybin… - Nature reviews …, 2022 - nature.com
Menstruation is a physiological process that is typically uncomplicated. However, up to one
third of women globally will be affected by abnormal uterine bleeding (AUB) at some point in …

Progesterone signaling and uterine fibroid pathogenesis; molecular mechanisms and potential therapeutics

M Ali, M Ciebiera, S Vafaei, S Alkhrait, HY Chen… - Cells, 2023 - mdpi.com
Uterine fibroids (UFs) are the most important benign neoplastic threat to women's health
worldwide, with a prevalence of up to 80% in premenopausal women, and can cause heavy …

Therapeutic options for the management of abnormal uterine bleeding

B MacGregor, MG Munro… - International Journal of …, 2023 - Wiley Online Library
Just as the investigation of abnormal uterine bleeding (AUB) is approached systematically
using the two FIGO systems for AUB in the reproductive years, treatment options can be …

Clinical efficacy, pharmacokinetics, and safety of the available medical options in the treatment of endometriosis-related pelvic pain: a scoping review

M Mikuš, M Šprem Goldštajn, AS Laganà, F Vukorepa… - Pharmaceuticals, 2023 - mdpi.com
Background: In this scoping review, we sought to identify published studies evaluating the
drugs currently used in the treatment of endometriosis-related pelvic pain, with reflection on …

Spatial definition of the human progesterone receptor-B transcriptional complex

X Yu, P Yi, AK Panigrahi, LEV Lumahan, JP Lydon… - Iscience, 2022 - cell.com
We report the quaternary structure of core transcriptional complex for the full-length human
progesterone receptor-B (PR-B) homodimer with primary coactivator steroid receptor …

Current and emerging treatment options for uterine fibroids

M Ali, M Ciebiera, M Wlodarczyk, S Alkhrait, E Maajid… - Drugs, 2023 - Springer
Uterine fibroids are the most common benign neoplasm of the female reproductive tract in
reproductive age women. Their prevalence is age dependent and can be detected in up to …

Premenstrual syndrome and premenstrual dysphoric disorder as centrally based disorders

RE Nappi, L Cucinella, D Bosoni, A Righi, F Battista… - Endocrines, 2022 - mdpi.com
Premenstrual syndrome (PMS) and premenstrual dysphoric disorder (PMDD) encompass a
variety of symptoms that occur during the luteal phase of the menstrual cycle and impair …

Next step in the development of mesoprogestins: the preclinical profile of EC313

K Błaszczak-Świątkiewicz, A Krupa, E Mnich… - Frontiers in …, 2023 - frontiersin.org
Introduction The pharmacological target for progesterone, different progestins, and Selective
Progesterone Receptor Modulators (SPRMs) is the nuclear progesterone receptor (PR) …

The latest advances in the pharmacological management of endometriosis

G Hartner, H Husslein, L Kuessel… - Expert Opinion on …, 2023 - Taylor & Francis
Introduction Endometriosis is a benign disease, characterized by a wide range of symptoms
and different degrees of severity, which is why therapy should be individually adapted to the …

Design, Synthesis, and Evaluation of B-(Trifluoromethyl)phenyl Phosphine–Borane Derivatives as Novel Progesterone Receptor Antagonists

Y Miyajima, K Ochiai, S Fujii - Molecules, 2024 - mdpi.com
We previously revealed that phosphine–boranes can function as molecular frameworks for
biofunctional molecules. In the present study, we exploited the diversity of available …