Uterine bleeding: how understanding endometrial physiology underpins menstrual health
V Jain, RR Chodankar, JA Maybin… - Nature reviews …, 2022 - nature.com
Menstruation is a physiological process that is typically uncomplicated. However, up to one
third of women globally will be affected by abnormal uterine bleeding (AUB) at some point in …
third of women globally will be affected by abnormal uterine bleeding (AUB) at some point in …
Progesterone signaling and uterine fibroid pathogenesis; molecular mechanisms and potential therapeutics
Uterine fibroids (UFs) are the most important benign neoplastic threat to women's health
worldwide, with a prevalence of up to 80% in premenopausal women, and can cause heavy …
worldwide, with a prevalence of up to 80% in premenopausal women, and can cause heavy …
Therapeutic options for the management of abnormal uterine bleeding
B MacGregor, MG Munro… - International Journal of …, 2023 - Wiley Online Library
Just as the investigation of abnormal uterine bleeding (AUB) is approached systematically
using the two FIGO systems for AUB in the reproductive years, treatment options can be …
using the two FIGO systems for AUB in the reproductive years, treatment options can be …
Clinical efficacy, pharmacokinetics, and safety of the available medical options in the treatment of endometriosis-related pelvic pain: a scoping review
M Mikuš, M Šprem Goldštajn, AS Laganà, F Vukorepa… - Pharmaceuticals, 2023 - mdpi.com
Background: In this scoping review, we sought to identify published studies evaluating the
drugs currently used in the treatment of endometriosis-related pelvic pain, with reflection on …
drugs currently used in the treatment of endometriosis-related pelvic pain, with reflection on …
Spatial definition of the human progesterone receptor-B transcriptional complex
We report the quaternary structure of core transcriptional complex for the full-length human
progesterone receptor-B (PR-B) homodimer with primary coactivator steroid receptor …
progesterone receptor-B (PR-B) homodimer with primary coactivator steroid receptor …
Current and emerging treatment options for uterine fibroids
M Ali, M Ciebiera, M Wlodarczyk, S Alkhrait, E Maajid… - Drugs, 2023 - Springer
Uterine fibroids are the most common benign neoplasm of the female reproductive tract in
reproductive age women. Their prevalence is age dependent and can be detected in up to …
reproductive age women. Their prevalence is age dependent and can be detected in up to …
Premenstrual syndrome and premenstrual dysphoric disorder as centrally based disorders
Premenstrual syndrome (PMS) and premenstrual dysphoric disorder (PMDD) encompass a
variety of symptoms that occur during the luteal phase of the menstrual cycle and impair …
variety of symptoms that occur during the luteal phase of the menstrual cycle and impair …
Next step in the development of mesoprogestins: the preclinical profile of EC313
K Błaszczak-Świątkiewicz, A Krupa, E Mnich… - Frontiers in …, 2023 - frontiersin.org
Introduction The pharmacological target for progesterone, different progestins, and Selective
Progesterone Receptor Modulators (SPRMs) is the nuclear progesterone receptor (PR) …
Progesterone Receptor Modulators (SPRMs) is the nuclear progesterone receptor (PR) …
The latest advances in the pharmacological management of endometriosis
G Hartner, H Husslein, L Kuessel… - Expert Opinion on …, 2023 - Taylor & Francis
Introduction Endometriosis is a benign disease, characterized by a wide range of symptoms
and different degrees of severity, which is why therapy should be individually adapted to the …
and different degrees of severity, which is why therapy should be individually adapted to the …
Design, Synthesis, and Evaluation of B-(Trifluoromethyl)phenyl Phosphine–Borane Derivatives as Novel Progesterone Receptor Antagonists
We previously revealed that phosphine–boranes can function as molecular frameworks for
biofunctional molecules. In the present study, we exploited the diversity of available …
biofunctional molecules. In the present study, we exploited the diversity of available …