Growing evidences suggest that the fibroblast growth factor/FGF receptor (FGF/FGFR)
signaling has crucial roles in a multitude of processes during embryonic development and …

Cardiac hypertrophy can be defined as an increase in heart mass. Pathological cardiac
hypertrophy (heart growth that occurs in settings of disease, eg hypertension) is a key risk …

The discovery that mammalian cells have the ability to synthesize the free radical nitric oxide
(NO) has stimulated an extraordinary impetus for scientific research in all the fields of …

Type I programmed cell death (PCD) or apoptosis is critical for cellular self-destruction for a
variety of processes such as development or the prevention of oncogenic transformation …

Mitochondria play an important role in cell death and cardioprotection. During ischemia,
when ATP is progressively depleted, ion pumps cannot function resulting in a rise in calcium …

Background Sunitinib, a multitargeted tyrosine-kinase inhibitor, which is approved by both
US and European Commission regulatory agencies for clinical use, extends survival of …

Ventricular remodelling describes structural changes in the left ventricle in response to
chronic alterations in loading conditions, with three major patterns: concentric remodelling …

Imatinib mesylate (Gleevec) is a small-molecule inhibitor of the fusion protein Bcr-Abl, the
causal agent in chronic myelogenous leukemia. Here we report ten individuals who …

Data from the Women's Health Study show that serum levels of growth-differentiation factor-
15 (GDF-15), a distant member of the transforming growth factor-β superfamily, are an …

Abstract MicroRNA-125b (miR-125b) reduces myocardial infarct area and restrains
myocardial ischemia reperfusion injury (I/R). In this study, we aimed to investigate the effect …