Antitumoral activity of snake venom proteins: new trends in cancer therapy
LA Calderon, JC Sobrinho, KD Zaqueo… - BioMed research …, 2014 - Wiley Online Library
For more than half a century, cytotoxic agents have been investigated as a possible
treatment for cancer. Research on animal venoms has revealed their high toxicity on tissues …
treatment for cancer. Research on animal venoms has revealed their high toxicity on tissues …
[HTML][HTML] Snake venoms and hemostasis
Q Lu, JM Clemetson, KJ Clemetson - Journal of Thrombosis and …, 2005 - Elsevier
Snake venoms are complex mixtures of biologically active proteins and peptides. Many of
them affect hemostasis by activating or inhibiting coagulant factors or platelets, or by …
them affect hemostasis by activating or inhibiting coagulant factors or platelets, or by …
[HTML][HTML] Disintegrins from snake venoms and their applications in cancer research and therapy
JKA Macêdo, JW Fox… - Current protein & peptide …, 2015 - ncbi.nlm.nih.gov
Integrins regulate diverse functions in cancer pathology and in tumor cell development and
contribute to important processes such as cell shape, survival, proliferation, transcription …
contribute to important processes such as cell shape, survival, proliferation, transcription …
[HTML][HTML] Venom-based peptide therapy: Insights into anti-cancer mechanism
R Ma, R Mahadevappa, HF Kwok - Oncotarget, 2017 - ncbi.nlm.nih.gov
The 5-year relative survival rate of all types of cancer has increased significantly over the
past three decades partly due to the targeted therapy. However, still there are many targeted …
past three decades partly due to the targeted therapy. However, still there are many targeted …
[HTML][HTML] Effects of animal venoms and toxins on hallmarks of cancer
Animal venoms are a cocktail of proteins and peptides, targeting vital physiological
processes. Venoms have evolved to assist in the capture and digestion of prey. Key venom …
processes. Venoms have evolved to assist in the capture and digestion of prey. Key venom …
Mechanistic insights of snake venom disintegrins in cancer treatment
Snake venoms are a potential source of various enzymatic and non-enzymatic compounds
with a defensive role for the host. Various peptides with significant medicinal properties have …
with a defensive role for the host. Various peptides with significant medicinal properties have …
Intravenous liposomal delivery of the snake venom disintegrin contortrostatin limits breast cancer progression
S Swenson, F Costa, R Minea, RP Sherwin… - Molecular Cancer …, 2004 - AACR
Despite significant research in this area, metastatic breast cancer remains a disease with a
poor prognosis. Until an effective therapy is developed, it is imperative that new treatment …
poor prognosis. Until an effective therapy is developed, it is imperative that new treatment …
A novel αvβ3-blocking disintegrin containing the RGD motive, DisBa-01, inhibits bFGF-induced angiogenesis and melanoma metastasis
OHP Ramos, A Kauskot, MR Cominetti… - Clinical & experimental …, 2008 - Springer
The integrin α v β 3 is involved in multiple aspects of malignant cancer, including tumor
angiogenesis and metastasis, which makes the receptor a key target for the development of …
angiogenesis and metastasis, which makes the receptor a key target for the development of …
[HTML][HTML] Biological effects of animal venoms on the human immune system
Z Avalo, MC Barrera, M Agudelo-Delgado, GJ Tobón… - Toxins, 2022 - mdpi.com
Venoms are products of specialized glands and serve many living organisms to immobilize
and kill prey, start digestive processes and act as a defense mechanism. Venoms affect …
and kill prey, start digestive processes and act as a defense mechanism. Venoms affect …
Snake venom components in medicine: From the symbolic rod of Asclepius to tangible medical research and application
MI Estevão-Costa, R Sanz-Soler… - The international journal …, 2018 - Elsevier
Both mythologically and logically, snakes have always fascinated man. Snakes have
attracted both awe and fear not only because of the elegant movement of their limbless …
attracted both awe and fear not only because of the elegant movement of their limbless …