Transcription factors (TFs) represent key biological players in diseases including cancer,
autoimmunity, diabetes and cardiovascular disease. However, outside nuclear receptors …

Background Melatonin is an indole hormone secreted primarily by the pineal gland that
showing anti-oxidant, anti-inflammatory and anti-apoptotic capacity. It can play an important …

One of the adverse outcomes of acute inflammatory response is progressing to the chronic
stage or transforming into an aggressive process, which can develop rapidly and result in …

Simple Summary Since its first description 35 years ago, the transcription factor NF-κB
(nuclear factor κ-light-chain-enhancer of activated B cells) has been shown to be a key …

Multiple sclerosis (MS) is a debilitating autoimmune disease that impacts millions of patients
worldwide, disproportionately impacting women (4: 1), and often presenting at highly …

Mendelian randomization (MR) is a powerful approach for assessing the causal effect of
putative risk factors on an outcome, using genetic variants as instrumental variables. The …

Hypoxia is one of the most common pathological conditions, which can be induced by
multiple events, including ischemic injury, trauma, inflammation, tumors, etc. The body's …

Multiple sclerosis (MS) is a chronic, autoimmune and neuroinflammatory disease of the
central nervous system (CNS) mediated by autoreactive T cells directed against myelin …

The transcription factor nuclear factor-κB (NF-κB) is a critical regulator of the immune
response, inflammation, cell growth, and survival. Canonical and non-canonical pathways …

Neurological diseases such as stroke and multiple sclerosis are associated with high
morbidity and mortality, long-term disability, and social and economic burden. Therefore …