Human biomonitoring has become a primary tool for chemical exposure characterization in
a wide variety of contexts: population monitoring and characterization at a national level …

Advances in computer sciences and hardware combined with equally significant
developments in molecular biology and chemistry are providing toxicology with a powerful …

Humans are exposed to a number of ''heavy metals''such as cadmium, mercury and its
organic form methylmercury, uranium, lead, and other metals as well as metalloids, such as …

A key element of risk assessment is accounting for the full range of variability in response to
environmental exposures. Default dose-response methods typically assume a 10-fold …

Organosiloxanes are widely used in the formulation of a broad range of cosmetic and
personal care products (PCPs), including creams and lotions, bath soaps, shampoo and hair …

The application of chemical-specific toxicokinetic or toxicodynamic data to address
interspecies differences and human variability in the quantification of hazard has potential to …

The present paper summarizes the most important insights and findings of the EU NoMiracle
project with a focus on (1) risk assessment of chemical mixtures,(2) combinations of …

For non-genotoxic carcinogens,“thresholded toxicants”, Acceptable/Tolerable Daily Intakes
(ADI/TDI) represent a level of exposure “without appreciable health risk” when consumed …

Humans today are exposed to a plethora of chemicals in food whether of anthropogenic or
natural origin, and public-health agencies have developed risk-assessment methods to …

Background: Cultured human hepatocytes are the closest in vitro model to human liver and
constitute a very predictive model for drug metabolism in vivo. The variability observed in …