Adenosine is a naturally occurring nucleoside that is distributed ubiquitously throughout the
body as a metabolic intermediary. In the brain, adenosine functions as an important …

Mutations in the acid β-glucocerebrosidase (GBA1) gene, responsible for the lysosomal
storage disorder Gaucher's disease (GD), are the strongest genetic risk factor for Parkinson's …

While the G protein-coupled receptor (GPCR) oligomerization has been questioned during
the last fifteen years, the existence of a multi-receptor complex involving direct receptor …

G‐protein‐coupled receptors (GPCR s) are the largest family of integral membrane
receptors with key roles in regulating signaling pathways targeted by therapeutics, but are …

In vertebrates the “anti-reward-system” mainly is represented by the habenula and its medial
(MHb) and especially lateral (LHb) complexes. Considerable knowledge has accumulated …

G-protein-coupled receptors (GPCRs) are a superfamily of cell surface signaling proteins
that act as central molecular activators and integrators in all endocrine systems. Membrane …

Neuronal calcium (Ca2+)-binding proteins 1 and 2 (NECAB1/2) are members of the
phylogenetically conserved EF-hand Ca2+-binding protein superfamily. To date, NECABs …

Lineage-specific DNA-binding transcription factors regulate development by activating and
repressing particular set of genes required for the acquisition of a specific cell type. Pax6 is a …

Stress is adverse experience that require constant adaptation to reduce the emotional and
physiological burden, or “allostatic load”, of an individual. Despite their everyday …

As with the majority of G-protein-coupled receptors, all four of the adenosine receptor
subtypes are known to undergo agonist-induced regulation in the form of desensitization …