Alzheimer's disease (AD) is a progressive, neurodegenerative disorder that is characterized
by neurodegeneration, cognitive impairment, and an eventual inability to perform daily tasks …

The ε4 allele of the APOE gene encoding apolipoprotein E (apoE) is a strong genetic risk
factor for aging-related cognitive decline as well as late-onset Alzheimer's disease (AD) …

Background Soluble beta-amyloid (Aβ) can be cleared from the brain through various
mechanisms including enzymatic degradation, glial cell phagocytosis, transport across the …

Carrying the ε4 allele of the APOE gene encoding apolipoprotein E (APOE4) markedly
increases the risk for late-onset Alzheimer's disease (AD), in which APOE4 exacerbates the …

Importance The apolipoprotein E ε4 (APOE4) allele identifies a unique population that is at
significant risk for developing Alzheimer disease (AD). Docosahexaenoic acid (DHA) is an …

The updated “Unifying Hypothesis of Alzheimer's disease”(AD) is described that links all the
observed neuropathology in AD brain (ie, plaques, tangles, and cerebrovascular amyloid …

The brain, as one of the most lipid-rich organs, heavily relies on lipid transport and
distribution to maintain homeostasis and neuronal function. Lipid transport mediated by …

APOEε4 is the most well-established genetic risk factor for sporadic Alzheimer's disease and
is associated with cerebral amyloid-β. However, the association between APOEε4 and tau …

Importance Numerous studies have established the association of the commonAPOE ε2
andAPOEε4 alleles with Alzheimer disease (AD) risk across ancestries. Studies of the …

The function of ATP binding cassette protein A1 (ABCA1) is central to cholesterol
mobilization. Reduced ABCA1 expression or activity is implicated in Alzheimer's disease …