Background Carriers of the APOE ε4 allele are at increased risk of developing Alzheimer's
disease (AD), and have been shown to have reduced cerebral metabolic rate of glucose …

Abstract Alzheimer's disease (AD), the most common type of dementia worldwide, is
characterized by high levels of amyloid-β (Aβ) peptide and hyperphosphorylated tau protein …

Astrocytes and apolipoprotein E (apoE) play critical roles in cognitive function, not only
under physiological conditions but also in some pathological situations, particularly in the …

Background Lipid metabolism changes occur in early Alzheimer's disease (AD) patients. Yet
little is known about metabolic gene changes in early AD cortex. Methods The lipid …

Neurodegenerative diseases are characterized by the aggregation and deposition of
misfolded proteins in the brain, most prominently amyloid-β (Aβ), tau and α-synuclein (α …

Neural stem cell (NSC) damage has been reported in patients with Alzheimer's disease.
Intracellular Aβ plays a vital role in NSC damage. Heparan sulfate proteoglycans are potent …

Since its discovery as a genetic risk factor for Alzheimer's disease, the APOE4 allele has
been linked to the majority of the pathological findings associated with the disease …

Abstract Apolipoproteins CI, C-II, and C-III interact with ApoE to regulate lipoprotein
metabolism and contribute to Alzheimer's disease pathophysiology. In plasma, apoC-I and C …

Apolipoprotein E (apoE) has an important role in the pathogenesis of Alzheimer's disease
with its three isoforms having distinct effects on disease risk. Here, we assessed the …

Alzheimer's disease (AD) is a debilitating neurodegenerative disease characterized by the
accumulation of extracellular amyloid-β peptides (Aβ) within the cerebral parenchyma and …