Increasingly, epidemiologic and clinical data support the hypothesis that perturbations in the
gastrointestinal (GI) microbiota because of antibiotic use and dietary differences in …

Adult pulmonary Langerhans' cell histiocytosis is a rare disorder of unknown aetiology that
occurs predominantly in young smokers, with an incidence peak at 20–40 yrs of age. In …

Dendritic cells (DC) mediate airway Ag presentation and play key roles in asthma and
infections. Although DC subsets are known to perform different functions, their occurrence in …

Dendritic cells located at the body surfaces, eg skin, respiratory and gastrointestinal tract,
play an essential role in the induction of adaptive immune responses to pathogens and inert …

Migration of dendritic cells (DCs) to the draining lymph node (DLN) is required for the
activation of naive T cells. We show here that migration of DCs from the lung to the DLN after …

APCs, including dendritic cells (DC), are central to Ag surveillance in the respiratory tract
(RT). Research in this area is dominated by mouse studies on purportedly representative RT …

We investigated the fate of latex (LX) particles that were introduced into mice intranasally.
Macrophages acquired the vast majority of particles and outnumbered LX particle-bearing …

Chronic obstructive pulmonary disease (COPD), asthma and cystic fibrosis (CF) are distinct
respiratory diseases that share features such as the obstruction of small airways and …

This manuscript reviews the current literature on the importance of innate immune cells in
the control of influenza virus infections. Adaptive immune responses are critical for the …

Immune responses to viral infections involve a complex orchestration between innate
signals and adaptive responses of specific T and B cells. Anti-viral CD4 cells can direct CD8 …