Lipid peroxidation involves a cascade of reactions in which production of free radicals
occurs selectively in the lipid components of cellular membranes. Polyunsaturated fatty …

At the end of the 1980s, it was clearly demonstrated that cells produce nitric oxide and that
this gaseous molecule is involved in the regulation of the cardiovascular, immune and …

Although oxidants clearly possess the capacity to behave in a random and destructive
fashion, growing evidence suggests that in many instances the production of reactive …

Modulation of endogenous cellular defense mechanisms represents an innovative approach
to therapeutic intervention in diseases causing chronic tissue damage, such as in …

Reactive oxygen species (ROS) are produced at low levels in mammalian cells by various
metabolic processes, such as oxidative phosphorylation by the mitochondrial respiratory …

BACKGROUND/AIMS: Flavonoids, including quercetin, have been reported to have potent
hepatoprotective effects, which may be associated with HO-1 induction. However, since the …

Ferulic acid (FA) is a polyphenol very abundant in vegetables and maize bran. Several lines
of evidence have shown that FA acts as a potent antioxidant in vitro, due to its ability to …

Understanding mechanisms of aging and determinants of life span will help to reduce age-
related morbidity and facilitate healthy aging. Average lifespan has increased over the last …

Fever is a cardinal symptom of infectious or inflammatory insults, but it can also arise from
noninfectious causes. The fever-inducing agent that has been used most frequently in …

The predominant molecular symptom of aging is the accumulation of altered gene products.
Moreover, several conditions including protein, lipid or glucose oxidation disrupt redox …