Since its clinical introduction in 1998, the topoisomerase I inhibitor irinotecan has been
widely used in the treatment of solid tumors, including colorectal, pancreatic, and lung …

UDP-glycosyltransferases (UGTs) catalyze the covalent addition of sugars to a broad range
of lipophilic molecules. This biotransformation plays a critical role in elimination of a broad …

Pharmacokinetics Acetaminophen has a high oral bioavailability (88%); it is well absorbed
and reaches the peak blood concentration within 90min after ingestion [5]. APAP is not …

Irinotecan hydrochloride is a camptothecin derivative that exerts antitumor activity against a
variety of tumors. SN-38 produced in the body by carboxylesterase is the active metabolite of …

Icterus neonatorum, or neonatal jaundice, has long been recognized. 1 The term
“kernicterus” was introduced in the early 1900s to refer to the yellow staining of the basal …

The widespread availability and frequent use of serum chemistry tests have resulted in a
dramatic increase in the number of normal and abnormal liver chemistry test values that …

Inherited disorders of hyperbilirubinemia may be caused by increased bilirubin production
or decreased bilirubin clearance. Reduced hepatic bilirubin clearance can be due to …

Purpose Severe toxicity is commonly observed in cancer patients receiving irinotecan. UDP-
glucuronosyltransferase 1A1 (UGT1A1) catalyzes the glucuronidation of the active …

Purpose Etoposide and cisplatin (EP) has been a standard treatment for extensive-disease
small-cell lung cancer (SCLC). An earlier phase III trial reported improved survival for …

Irinotecan unexpectedly causes severe toxicity of leukopenia or diarrhea. Irinotecan is
metabolized to form active SN-38, which is further conjugated and detoxified by UDP …