3D human tissue models and microphysiological systems for HIV and related comorbidities

DE Yin, AC Palin, TB Lombo, RN Mahon, B Poon… - Trends in …, 2023 - cell.com
Abstract Three-dimensional (3D) human tissue models/microphysiological systems (eg,
organs-on-chips, organoids, and tissue explants) model HIV and related comorbidities and …

Lymph node metastasis and tumor-educated immune tolerance: Potential therapeutic targets against distant metastasis

JM Peng, YL Su - Biochemical pharmacology, 2023 - Elsevier
Lymph node metastasis has been shown to positively associated with the prognosis of many
cancers. However, in clinical treatment, lymphadenectomy is not always successful …

Modeling Structural Elements and Functional Responses to Lymphatic‐Delivered Cues in a Murine Lymph Node on a Chip

C Mazzaglia, H Munir, IM Lei, M Gerigk… - Advanced …, 2024 - Wiley Online Library
Lymph nodes (LNs) are organs of the immune system, critical for maintenance of
homeostasis and initiation of immune responses, yet there are few models that accurately …

An organotypic human lymph node model reveals the importance of fibroblastic reticular cells for dendritic cell function

AI Morrison, AM Mikula, SW Spiekstra, M de Kok… - Tissue Engineering and …, 2024 - Springer
Abstract Background: Human lymph node (HuLN) models have emerged with invaluable
potential for immunological research and therapeutic application given their fundamental …

[HTML][HTML] Targeting lymph nodes for enhanced cancer vaccination: from nanotechnology to tissue engineering

J Wang, Z Zhang, R Liang, W Chen, Q Li, J Xu… - Materials Today Bio, 2024 - Elsevier
Lymph nodes (LNs) occupy a critical position in initiating and augmenting immune
responses, both spatially and functionally. In cancer immunotherapy, tumor-specific …

[HTML][HTML] Lymph Node-on-Chip Technology: Cutting-Edge Advances in Immune Microenvironment Simulation

Q Wang, Y Yang, Z Chen, B Li, Y Niu, X Li - Pharmaceutics, 2024 - mdpi.com
Organ-on-a-chip technology is attracting growing interest across various domains as a
crucial platform for drug screening and testing and is set to play a significant role in precision …

Bridging Smart Nanosystems with Clinically Relevant Models and Advanced Imaging for Precision Drug Delivery

Q Zhou, Q Liu, Y Wang, J Chen, O Schmid… - Advanced …, 2024 - Wiley Online Library
Intracellular delivery of nano‐drug‐carriers (NDC) to specific cells, diseased regions, or
solid tumors has entered the era of precision medicine that requires systematic knowledge …

Modelling structural and cellular elements and functional responses to lymphatic-delivered cues in a murine lymph node on a chip

C Mazzaglia, H Munir, I Man Lei… - Advanced …, 2024 - nottingham-repository.worktribe.com
Lymph nodes (LNs) are organs of the immune system, critical for maintenance of
homeostasis and initiation of immune responses, yet there are few models that accurately …

Recapitulating memory B cell responses in a Lymphoid Organ-Chip to evaluate mRNA vaccine boosting strategies

R Jeger-Madiot, D Planas, I Staropoli, J Kervevan… - bioRxiv, 2024 - biorxiv.org
Predicting the immunogenicity of candidate vaccines in humans remains a challenge. To
address this issue, we developed a Lymphoid Organ-Chip (LO chip) model based on a …

Multi-organ immunity on a 3D-printed multi-tissue chip with tubing-free impeller pump

SR Cook, AG Ball, A Mohammad, RR Pompano - bioRxiv, 2024 - biorxiv.org
Multi-organ-on-chip systems (MOOCs) have the potential to mimic communication between
organ systems and reveal mechanisms of health and disease. However, many existing …