Abstract Steroid 17-hydroxylase 17, 20-lyase (cytochrome P450c17, P450 17A1, CYP17A1)
catalyzes two major reactions: steroid 17-hydroxylation followed by the 17, 20-lyase …

In the biosynthesis of steroid hormones, P450c17 is the single enzyme that catalyzes both
the 17α-hydroxylation of 21-carbon steroids and the 17, 20-lyase activity that cleaves the C …

Deficient activities of multiple steroidogenic enzymes have been reported without and with
Antley-Bixler syndrome (ABS), but mutations of corresponding cytochrome P450 enzymes …

Steroid biosynthesis and metabolism are reflected by the serum steroid metabolome and, in
even more detail, by the 24-hour urine steroid metabolome, which can provide unique …

Dihydrotestosterone (DHT) is the androgen responsible for formation of the male external
genitalia during embryogenesis and for most androgen-mediated events at male puberty. In …

Human sexual determination is initiated by a cascade of genes that lead to the development
of the fetal gonad. Whereas development of the female external genitalia does not require …

Congenital adrenal hyperplasia (CAH) is one of the most common inherited metabolic
disorders. It comprises a group of autosomal recessive disorders caused by the deficiency of …

Background Congenital adrenal hyperplasia with apparent combined P450C17 and
P450C21 deficiency is associated with accumulation of steroid metabolites, indicating …

Much of P450 research has always been done with the view of appUcation to humans, even
when done with experimental animals and microorganisms. Research with the human …

Cytochrome P450 enzymes catalyze the degradation of drugs and xenobiotics, but also
catalyze a wide variety of biosynthetic processes, including most steps in steroidogenesis …