P450 oxidoreductase (POR) is the obligatory flavoprotein intermediate that transfers
electrons from reduced nicotinamide adenine dinucleotide phosphate (NADPH) to all …

P450c17 commands a central role in human steroidogenesis as the qualitative regulator of
steroid hormone flux (Fig. 1). Analysis of P450c17 deficiencies in humans illustrates many …

Adrenal corticosteroids are essential for life, and an appreciation of the mechanisms
underpinning their synthesis, secretion, and mode of action in normal physiology is essential …

The biosynthesis of steroid hormones requires the coordinated expression of the enzymes
that comprise the pathways via which specific hormones are synthesized. These pathways …

The Leydig cells of the testis have the capacity to biosynthesize testosterone from
cholesterol. Testosterone and its metabolically activated product dihydrotestosterone are …

Congenital adrenal hyperplasia (CAH) is a group of genetic disorders of adrenal
steroidogenesis that impair cortisol synthesis, with compensatory increases in ACTH leading …

We performed molecular genetic analysis of 24 subjects from 19 families with 17-
hydroxylase deficiency in Brazil. Of 7 novel CYP17 mutations, 2 (W406R and R362C) …

The adrenal cortex produces dozens of steroids having varying degrees of glucocorticoid,
mineralocorticoid, and androgenic activity. Cortisol, the principal glucocorticoid, and …

Abstract P450c17 (17α-hydroxylase/17, 20-lyase) catalyzes steroid 17α-hydroxylase and 17,
20-lyase activities in the biosynthesis of androgens and estrogens. These two activities are …

Androgens and estrogens are made from dehydroepiandrosterone (DHEA), which is made
from cholesterol via four steps. First, cholesterol enters the mitochondria with the assistance …