P450 oxidoreductase (POR) transports electrons from NADPH to all microsomal cytochrome
P450 enzymes, including steroidogenic P450c17, P450c21 and P450aro. Severe POR …

Abstract Context: Cytochrome P450c17 (P450c17) is a bifunctional enzyme necessary for
the production of glucocorticoids (17-hydroxylase activity) and sex steroids (17, 20-lyase …

Context: Isolated 17, 20 lyase deficiency is commonly defined by apparently normal 17α-
hydroxylase activity but severely reduced 17, 20 lyase activity of the bifunctional enzyme …

Abstract NADPH-cytochrome P450 oxidoreductase (POR) is the obligatory flavoprotein
electron donor to microsomal cytochromes P450 (P450). POR is a diflavin protein containing …

P450c17 deficiency is an autosomal recessive disorder and a rare cause of congenital
adrenal hyperplasia characterized by hypertension, hypokalemia, and impaired production …

Prostate cancer is the most common form of cancer in males in the United States, and the
second leading cause of cancer death. Initially, most cases of prostate cancer respond well …

The role of steroidal inhibitors of androgen biosynthesis as potential weapons in the
treatment of prostatic diseases, such as benign prostatic hyperplasia and prostatic cancer …

Sex steroids, both androgens and oestrogens, are made from dehydroepiandrosterone
(DHEA). The biosynthesis of DHEA from cholesterol entails four steps. First, cholesterol …

P450 oxidoreductase (POR) deficiency is an autosomal recessive disorder of
steroidogenesis with multiple clinical manifestations. POR is the electron donor for all …

Disorders of adrenal steroidogenesis comprise autosomal recessive conditions affecting
steroidogenic enzymes of the adrenal cortex. Those are located within the 3 major branches …