Human cytochrome P450 17A1 is required for all androgen biosynthesis and is the target of
abiraterone, a drug used widely to treat advanced prostate cancer. P450 17A1 catalyzes …

A single enzyme, microsomal P450c17, catalyzes the 17α-hydroxylase activity needed to
make cortisol and the subsequent 17, 20 lyase activity needed to produce the 19-carbon …

Congenital forms of endocrine hypertension are rare and potentially life-threatening
disorders, primarily caused by genetic defects affecting adrenal steroid synthesis and …

The 5α-reduction of testosterone in target tissues is a key step in androgen physiology;
however, 5α-reduced C19 steroids are sometimes synthesized in testis via a pathway that …

The biosynthesis of dehydroepiandrosterone (DHEA) from cholesterol involves only two
enzymes, both cytochrome P450s. The conversion of cholesterol to pregnenolone is …

The problem of donor–acceptor recognition has been the most important and intriguing one
in the area of P450 research. The present review outlines the topological background of …

The adrenal has played a major role in the history of pediatric endocrinology. Cases of
congenital adrenal hyperplasia (CAH) were reported in the 19th century, leading to the …

Neurosteroids are important endogenous regulators of γ-aminobutryic acid (GABAA) and N-
methyl-d-aspartate (NMDA) receptors and also influence neuronal morphology and function …

Most steroidogenesis disorders are caused by mutations in genes encoding the
steroidogenic enzymes, but work in the past 20 years has identified related disorders …

Summary background Defective male sex differentiation in patients with hypoplasia of
Leydig cells (LCH) is caused by deficient LH receptor signal transduction. To further …