Annexins: from structure to function

V Gerke, SE Moss - Physiological reviews, 2002 - journals.physiology.org
Annexins are Ca2+ and phospholipid binding proteins forming an evolutionary conserved
multigene family with members of the family being expressed throughout animal and plant …

Annexin A1 as a regulator of immune response in cancer

TG Araújo, STS Mota, HSV Ferreira, MA Ribeiro… - Cells, 2021 - mdpi.com
Annexin A1 is a 37 kDa phospholipid-binding protein that is expressed in many tissues and
cell types, including leukocytes, lymphocytes and epithelial cells. Although Annexin A1 has …

Annexin A1 and the regulation of innate and adaptive immunity

FNE Gavins, MJ Hickey - Frontiers in immunology, 2012 - frontiersin.org
Inflammation is the body's way of defending itself against noxious stimuli and pathogens.
Under normal circumstances, the body is able to eliminate the insult and subsequently …

Annexin 1 and the biology of the neutrophil

M Perretti, RJ Flower - Journal of leukocyte biology, 2004 - academic.oup.com
This overview will focus on one aspect of neutrophil biology, which is the selective activation
of the annexin 1 system in relation to the process of cell extravasation. Besides the current …

Annexin 1 cleavage in activated neutrophils: a pivotal role for proteinase 3

L Vong, F D'Acquisto, M Pederzoli-Ribeil… - Journal of Biological …, 2007 - ASBMB
Annexin 1 is an anti-inflammatory protein that plays a key role in innate immunity by
modulating the activation of several types of cells, including neutrophils. Here we have …

Annexins as intracellular calcium sensors

K Monastyrskaya, EB Babiychuk, A Hostettler… - Cell calcium, 2007 - Elsevier
The annexins are a multigene family of Ca2+-and charged phospholipid-binding proteins.
Although they have been ascribed with diverse functions, there is no consensus about the …

Cleavage of annexin A1 by ADAM10 during secondary necrosis generates a monocytic “find-me” signal

KE Blume, S Soeroes, H Keppeler… - The Journal of …, 2012 - journals.aai.org
Annexin A1 is an intracellular calcium/phospholipid-binding protein that is involved in
membrane organization and the regulation of the immune system. It has been attributed an …

Neutrophil interaction with inflamed postcapillary venule endothelium alters annexin 1 expression

SM Oliani, MJ Paul-Clark, HC Christian… - The American journal of …, 2001 - Elsevier
Annexin 1 (ANX-A1) exerts antimigratory actions in several models of acute and chronic
inflammation. This is related to its ability to mimic the effect of endogenous ANX-A1 that is …

Selective degradation of annexins by chaperone-mediated autophagy

AM Cuervo, AV Gomes, JA Barnes, JF Dice - Journal of Biological …, 2000 - ASBMB
Annexins are a family of proteins that bind phospholipids in a calcium-dependent manner.
Analysis of the sequences of the different members of the annexin family revealed the …

Rab5a GTPase regulates fusion between pathogen-containing phagosomes and cytoplasmic organelles in human neutrophils

N Perskvist, K Roberg, A Kulyté… - Journal of cell …, 2002 - journals.biologists.com
Biogenesis of phagolysosomes proceeds through a sequential series of interactions with
endocytic organelles, a process known to be regulated by Rab and SNARE proteins. The …