Single-cell ribonucleic acid sequencing is becoming widely employed to study biological
processes at a novel resolution depth. The ability to analyse transcriptomes of multiple …

Historically believed to be a homogeneous cell type that is often overlooked, fibroblasts are
more and more understood to be heterogeneous in nature. Though the mechanisms behind …

Background Basophils are rare but important effector cells in many allergic disorders.
Contrary to their early progenitors, the terminal developmental processes of basophils in …

Cells with the same genome can exist in different phenotypes and can change between
distinct phenotypes when subject to specific stimuli and microenvironments. Some examples …

Although medical science has been fully developed, due to the high heterogeneity of triple-
negative breast cancer (TNBC), it is still difficult to use reasonable and precise treatment. In …

Lung cancer patients tend to have strong intratumoral and intertumoral heterogeneity and
complex tumor microenvironment, which are major contributors to the efficacy of and drug …

The mortality rate of cardiovascular disease ranks first in the world. Its pathogenesis involves
not only internal factors such as immunity, inflammation, metabolic disorders, and self …

Myeloproliferative neoplasms (MPN) are a group of clonal stem cell–derived hematopoietic
malignancies driven by aberrant Janus kinase-signal transducer and activator of …

Gene fusions can play important roles in tumor initiation and progression. While fusion
detection so far has been from bulk samples, full-length single-cell RNA sequencing (scRNA …

Single-cell RNA sequencing (scRNA-seq) is currently one of the most powerful techniques
available to study the transcriptional response of thousands of cells to an external …