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RNA velocity estimation is a potentially powerful tool to reveal the directionality of
transcriptional changes in single-cell RNA-sequencing data, but it lacks accuracy, absent …

Bladder cancer (BC) is the 10th most common cancer worldwide, with about 0.5 million
reported new cases and about 0.2 million deaths per year. In this scoping review, we …

In spite of major efforts and investment in development of psychiatric drugs, many clinical
trials have failed in recent decades, and clinicians still prescribe drugs that were discovered …

Motivation Identification of genomic, molecular and clinical markers prognostic of patient
survival is important for developing personalized disease prevention, diagnostic and …

Single-cell transcriptomic technologies enable the uncovering and characterization of
cellular heterogeneity and pave the way for studies aiming at understanding the origin and …

Over the past decade, single-cell RNA-sequencing (scRNA-seq) has made it possible to
study the cellular diversity of a broad range of organisms. Technological advances in single …

Viral infections pose significant public health challenges, exemplified by the global impact of
COVID-19 caused by SARS-CoV-2. Understanding the intricate molecular mechanisms …

Environmental factors, in particular viral infections, are thought to have an important role in
the pathogenesis of type 1 diabetes mellitus (T1DM). The COVID-19 pandemic reinforced …

High dimensionality and noise have limited the new biological insights that can be
discovered in scRNA-seq data. While dimensionality reduction tools have been developed …