Trigeminal neuralgia is a very painful neurological condition with severe, stimulus-evoked,
short-lasting stabbing pain attacks in the face. The past decade has offered new insights into …

Rationale Psychedelic research continues to garner significant public and scientific interest
with a growing number of clinical studies examining a wide range of conditions and …

Background Chronic pain conditions impose significant burdens worldwide.
Pharmacological treatments like opioids have limitations. Non-invasive non …

Abstract Treatment of neuropathic pain remains inadequate despite the elucidation of
multiple pathophysiological mechanisms and the development of promising therapeutic …

Background Trigeminal neuralgia is a severe facial pain disorder. Microvascular
decompression is first choice surgical treatment of patients with classical TN. There exist few …

Gastrointestinal (GI) pain—a form of visceral pain—is common in some disorders, such as
irritable bowel syndrome, Crohn's disease and pancreatitis. However, identifying the cause …

Interpreting randomized clinical trials (RCTs) is crucial to making decisions regarding the
use of analgesic treatments in clinical practice. In this article, we report on an Initiative on …

Motor cortex stimulation via surgically implanted electrodes has been used as an off-label
treatment for chronic neuropathic pain, but its efficacy has not been fully established. We …

Introduction: Clinical and laboratory studies demonstrate that placebo and nocebo effects
influence various symptoms and conditions after the administration of both inert and active …

Spinal cord stimulation (SCS) is an interventional nonpharmacologic treatment used for
chronic pain and other indications. Methods for evaluating the safety and efficacy of SCS …