The JAK/STAT signaling pathway: from bench to clinic

X Hu, J Li, M Fu, X Zhao, W Wang - Signal transduction and targeted …, 2021 - nature.com
The Janus kinase/signal transducer and activator of transcription (JAK/STAT) signaling
pathway was discovered more than a quarter-century ago. As a fulcrum of many vital cellular …

JAK-STAT signaling: a double-edged sword of immune regulation and cancer progression

KL Owen, NK Brockwell, BS Parker - Cancers, 2019 - mdpi.com
Janus kinase-signal transducer and activator of transcription (JAK-STAT) signaling mediates
almost all immune regulatory processes, including those that are involved in tumor cell …

The therapeutic potential of curcumin: A review of clinical trials

B Salehi, Z Stojanović-Radić, J Matejić… - European journal of …, 2019 - Elsevier
Curcuma longa L., its derived extracts and even its major compound curcumin has a long
history of use and doubtless effectiveness, reported through increasingly detailed in vitro, ex …

Antiviral and immunomodulatory activity of curcumin: A case for prophylactic therapy for COVID-19

RK Thimmulappa, KK Mudnakudu-Nagaraju… - Heliyon, 2021 - cell.com
Abstract Coronavirus disease-19 (COVID-19), a devastating respiratory illness caused by
SARS-associated coronavirus-2 (SARS-CoV-2), has already affected over 64 million people …

Curcumin: A natural modulator of immune cells in systemic lupus erythematosus

AA Momtazi-Borojeni, SM Haftcheshmeh… - Autoimmunity …, 2018 - Elsevier
Curcumin is a polyphenol natural product isolated from turmeric, interacting with different
cellular and molecular targets and, consequently, showing a wide range of pharmacological …

Involvement of gut microbiota, microbial metabolites and interaction with polyphenol in host immunometabolism

AWC Man, Y Zhou, N Xia, H Li - Nutrients, 2020 - mdpi.com
Immunological and metabolic processes are inextricably linked and important for
maintaining tissue and organismal health. Manipulation of cellular metabolism could be …

[PDF][PDF] Immunomodulatory, anti-inflammatory, and antioxidant effects of curcumin

N Boroumand, S Samarghandian… - Journal of Herbmed …, 2018 - pdfs.semanticscholar.org
Turmeric is a widely used spice derived from the rhizomes of Curcuma longa which belongs
to the ginger family (1). Having been used as a dietary spice, it has drawn scientists' …

Curcumin: a modulator of inflammatory signaling pathways in the immune system

KR Kahkhaie, A Mirhosseini, A Aliabadi… - …, 2019 - Springer
Curcumin is a natural compound derived from the spice, turmeric, that has been extensively
reported for its efficacy in controlling or treatment of several inflammatory diseases. There is …

Curcumin and its modified formulations on inflammatory bowel disease (IBD): The story so far and future outlook

A Karthikeyan, KN Young, M Moniruzzaman… - Pharmaceutics, 2021 - mdpi.com
Inflammatory bowel disease (IBD) is a chronic relapsing and remitting inflammatory disorder
of the small intestine and colon. IBD includes ulcerative colitis (UC) and Crohn's disease …

Stem cell-based therapies for inflammatory bowel disease

HM Zhang, S Yuan, H Meng, XT Hou, J Li… - International Journal of …, 2022 - mdpi.com
Inflammatory bowel disease (IBD) is a chronic, relapsing disease that severely affects
patients' quality of life. The exact cause of IBD is uncertain, but current studies suggest that …