It is of vital importance to reversibly mask and selectively activate bioactive agents for
advanced therapeutic and diagnostic purposes, aiming to efficiently suppress background …

Shiga toxins (Stxs) produced by Shiga toxin-producing bacteria Shigella dysenteriae
serotype 1 and select serotypes of Escherichia coli are primary virulence factors in the …

The selective activation of nanovectors in pathological tissues is of crucial importance to
achieve optimized therapeutic outcomes. However, conventional stimuli-responsive …

Disulfide bonds provide a bioactivatable connection with applications in imaging and
therapy. The circulation stability and intracellular release of disulfides are problematically …

Specialized cellular networks of oxidoreductases coordinate the dithiol/disulfide-exchange
reactions that control metabolism, protein regulation, and redox homeostasis. For probes to …

Background Aberrant glycosylation patterns play a crucial role in the development of cancer
cells as they promote tumor growth and aggressiveness. Lectins recognize carbohydrate …

Shiga toxins (Stxs), also known as Shiga-like toxins (SLT) or verotoxins (VT), constitute a
family of structurally and functionally related cytotoxic proteins produced by the enteric …

The chemical investigation of marine mollusks has led to the isolation of a wide variety of
bioactive metabolites, which evolved in marine organisms as favorable adaptations to …

Conventional targeted therapies for the treatment of cancer have limitations, including the
development of acquired resistance. However, novel alternatives have emerged in the form …

The B subunit pentamer verotoxin (VT aka Shiga toxin-Stx) binding to its cellular
glycosphingolipid (GSL) receptor, globotriaosyl ceramide (Gb3) mediates internalization and …