[HTML][HTML] Control of the embryonic stem cell state
RA Young - Cell, 2011 - cell.com
Embryonic stem cells and induced pluripotent stem cells hold great promise for regenerative
medicine. These cells can be propagated in culture in an undifferentiated state but can be …
medicine. These cells can be propagated in culture in an undifferentiated state but can be …
The nature of embryonic stem cells
G Martello, A Smith - Annual review of cell and developmental …, 2014 - annualreviews.org
Mouse embryonic stem (ES) cells perpetuate in vitro the broad developmental potential of
naïve founder cells in the preimplantation embryo. ES cells self-renew relentlessly in culture …
naïve founder cells in the preimplantation embryo. ES cells self-renew relentlessly in culture …
[HTML][HTML] Master transcription factors and mediator establish super-enhancers at key cell identity genes
Summary Master transcription factors Oct4, Sox2, and Nanog bind enhancer elements and
recruit Mediator to activate much of the gene expression program of pluripotent embryonic …
recruit Mediator to activate much of the gene expression program of pluripotent embryonic …
The RNA-binding protein repertoire of embryonic stem cells
RNA-binding proteins (RBPs) have essential roles in RNA-mediated gene regulation, and
yet annotation of RBPs is limited mainly to those with known RNA-binding domains. To …
yet annotation of RBPs is limited mainly to those with known RNA-binding domains. To …
[HTML][HTML] An evolutionarily conserved long noncoding RNA TUNA controls pluripotency and neural lineage commitment
Here, we generated a genome-scale shRNA library targeting long intergenic noncoding
RNAs (lincRNAs) in the mouse. We performed an unbiased loss-of-function study in mouse …
RNAs (lincRNAs) in the mouse. We performed an unbiased loss-of-function study in mouse …
Prioritizing candidate disease genes by network-based boosting of genome-wide association data
Network “guilt by association”(GBA) is a proven approach for identifying novel disease
genes based on the observation that similar mutational phenotypes arise from functionally …
genes based on the observation that similar mutational phenotypes arise from functionally …
[HTML][HTML] A Myc network accounts for similarities between embryonic stem and cancer cell transcription programs
Summary c-Myc (Myc) is an important transcriptional regulator in embryonic stem (ES) cells,
somatic cell reprogramming, and cancer. Here, we identify a Myc-centered regulatory …
somatic cell reprogramming, and cancer. Here, we identify a Myc-centered regulatory …
Lineage-specific enhancers activate self-renewal genes in macrophages and embryonic stem cells
EL Soucie, Z Weng, L Geirsdóttir, K Molawi, J Maurizio… - Science, 2016 - science.org
INTRODUCTION In many organs of the body, differentiated cells are frequently lost and
need to be replaced as part of normal homeostatic tissue maintenance or in response to …
need to be replaced as part of normal homeostatic tissue maintenance or in response to …
Structure of complete Pol II–DSIF–PAF–SPT6 transcription complex reveals RTF1 allosteric activation
Transcription by RNA polymerase II (Pol II) is carried out by an elongation complex. We
previously reported an activated porcine Pol II elongation complex, EC*, encompassing the …
previously reported an activated porcine Pol II elongation complex, EC*, encompassing the …
System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation
KTG Rigbolt, TA Prokhorova, V Akimov… - Science …, 2011 - science.org
To elucidate cellular events underlying the pluripotency of human embryonic stem cells
(hESCs), we performed parallel quantitative proteomic and phosphoproteomic analyses of …
(hESCs), we performed parallel quantitative proteomic and phosphoproteomic analyses of …