[HTML][HTML] Activation and function of NLRP3 inflammasome in bone and joint-related diseases

T Murakami, Y Nakaminami, Y Takahata… - International Journal of …, 2022 - mdpi.com
Inflammation is a pivotal response to a variety of stimuli, and inflammatory molecules such
as cytokines have central roles in the pathogenesis of various diseases, including bone and …

Melatonin: A novel candidate for the treatment of osteoarthritis

Y Zhang, T Liu, H Yang, F He, X Zhu - Ageing research reviews, 2022 - Elsevier
Osteoarthritis (OA), characterized by cartilage erosion, synovium inflammation, and
subchondral bone remodeling, is a common joint degenerative disease worldwide. OA …

[HTML][HTML] TRPV1 alleviates osteoarthritis by inhibiting M1 macrophage polarization via Ca2+/CaMKII/Nrf2 signaling pathway

Z Lv, X Xu, Z Sun, YX Yang, H Guo, J Li, K Sun… - Cell death & …, 2021 - nature.com
Osteoarthritis (OA) is the major course of joint deterioration, in which M1 macrophage-driven
synovitis exacerbates the pathological process. However, precise therapies for M1 …

Astragaloside IV alleviates cerebral ischemia‐reperfusion injury through NLRP3 Inflammasome‐mediated pyroptosis inhibition via activating Nrf2

L Xiao, Z Dai, W Tang, C Liu… - Oxidative medicine and …, 2021 - Wiley Online Library
As one of the fundamental components of Astragalus membranaceus, astragaloside IV (AST
IV) exerts protective effects against cerebral ischemia‐reperfusion injury (CIRI) …

Activating Nrf2 signalling alleviates osteoarthritis development by inhibiting inflammasome activation

Z Yan, W Qi, J Zhan, Z Lin, J Lin, X Xue… - Journal of Cellular …, 2020 - Wiley Online Library
Osteoarthritis (OA), which is characterized by proliferation of subchondral bone and the
degeneration of articular cartilage, is the most prevalent human arthritis. Nod‐like receptor …

Chondroitin sulfate microspheres anchored with drug-loaded liposomes play a dual antioxidant role in the treatment of osteoarthritis

Y He, M Sun, J Wang, X Yang, C Lin, L Ge, C Ying… - Acta Biomaterialia, 2022 - Elsevier
Reactive oxygen species (ROS) play a critical role in the pathogenesis of osteoarthritis. The
injection of a single antioxidant drug is characterized by low drug utilization and short …

[HTML][HTML] HK2: a potential regulator of osteoarthritis via glycolytic and non-glycolytic pathways

C Bao, S Zhu, K Song, C He - Cell Communication and Signaling, 2022 - Springer
Osteoarthritis (OA) is an age-related chronic degenerative joint disease where the main
characteristics include progressive degeneration of cartilage, varying degrees of synovitis …

[HTML][HTML] Melatonin attenuates smoking-induced atherosclerosis by activating the Nrf2 pathway via NLRP3 inflammasomes in endothelial cells

Z Zhao, X Wang, R Zhang, B Ma, S Niu, X Di… - Aging (Albany …, 2021 - ncbi.nlm.nih.gov
Substantial evidence suggests that the effects of smoking in atherosclerosis are associated
with inflammation mediated by endothelial cells. However, the mechanisms and potential …

An overview of anti-SARS-CoV-2 and anti-inflammatory potential of baicalein and its metabolite baicalin: insights into molecular mechanisms

B Dinda, M Dinda, S Dinda, UC De - European Journal of Medicinal …, 2023 - Elsevier
Abstract The current Coronavirus Disease 2019 (COVID-19) pandemic, caused by the
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), is highly contagious …

Polysaccharides from Polygonatum cyrtonema Hua prevent post-traumatic stress disorder behaviors in mice: mechanisms from the perspective of synaptic injury …

P Xie, L Chen, J Wang, X Wang, S Yang… - Journal of …, 2024 - Elsevier
Ethnopharmacological relevance According to traditional Chinese medicine (TCM) theory,
post-traumatic stress disorder (PTSD) is a kind of depression syndrome, and its occurrence …