The latest advances in high-throughput techniques during the past decade allowed the
systems biology field to expand significantly. Today, the focus of biologists has shifted from …

Background Lung cancer is the leading cause of the largest number of deaths worldwide
and lung adenocarcinoma is the most common form of lung cancer. In order to understand …

Lung cancer is the second most frequently diagnosed cancer type and responsible for the
highest number of cancer deaths worldwide. Lung adenocarcinoma (LUAD) and lung …

Given the fact that our biological existence is rooted in a complex system within our cells
with thousands of interactions among genes and metabolites, research community in …

Subpathways, which are defined as local gene subregions within a biological pathway, have
been reported to be associated with the occurrence and development of cancer. The recent …

Significance: Reductionist studies have contributed greatly to our understanding of the basic
biology of aging in recent years but we still do not understand fundamental mechanisms for …

Abstract Background The genus Potentilla is closely related to that of Fragaria, the
economically important strawberry genus. Potentilla micrantha is a species that does not …

In the era of network medicine, pathway analysis methods play a central role in the
prediction of phenotype from high throughput experiments. In this paper, we present a …

Gene set analysis (GSA) is one of the methods of choice for analyzing the results of current
omics studies; however, it has been mainly developed to analyze mRNA (microarray, RNA …

Accurate predictions of classification biomarkers and disease status are indispensable for
clinical cancer diagnosis and research. However, the robustness of conventional gene …