Type 2 diabetes mellitus (T2DM) is common and increasing in prevalence worldwide, with
devastating public health consequences. While peripheral insulin resistance is a key feature …

Alzheimer's disease is a progressive neurodegenerative disorder and the most common
cause of dementia that principally affects older adults. Pathogenic factors, such as oxidative …

Abstract Background Neurodegenerative diseases (NDDs), including Alzheimer's disease
(AD) and Parkinson's disease (PD), are associated with metabolic abnormalities. Integrative …

Obesity is increasing in prevalence across all age groups. Long-term obesity can lead to the
development of metabolic and cardiovascular diseases through its effects on adipose …

The E4 allele of apolipoprotein E (ApoE4) is a key genetic risk factor for late‐onset
Alzheimer's disease (AD), increasing the risk of developing the disease by up to three‐fold …

Alzheimer's disease (AD) drastically impacts cognitive and noncognitive behaviors in both
humans and animal models. Two hallmark proteins in AD, amyloid-β plaques and tau …

While high-fat diet (HFD)-induced obesity is a major threat to global public health, the effect
of HFD on cognition and insulin signaling during ageing remains controversial. The aim of …

This work aims to clarify the effect of dietary polyunsaturated fatty acid (PUFA) intake on the
adult brain affected by amyloid pathology. McGill-R-Thy1-APP transgenic (Tg) rat and …

Diet is a critical regulator for physiological metabolism and tissue homeostasis, with a close
relation to health and disease. As an important organ for digestion and absorption, the …

Alzheimer's disease (AD) is the most prevailing form of dementia, with long‐term high‐fat
diet (HFD) consumption being a pivotal contributor to AD pathogenesis. As microglial …